The PA-free cream
Comfrey cream or ointment labeled free of pyrrolizidine alkaloids
The form used in studies, made to remove most of the liver-harming compounds (PAs).
Good for: Bruises & bumps · Sore muscles
What variations of comfrey exist?
A plant made into creams and ointments that are rubbed on unbroken skin over sprains, bruises, and sore joints. It contains liver-toxic compounds called pyrrolizidine alkaloids, so it should never be taken by mouth. It comes in 3 forms, and they aren't all the same. Here's how they differ.
For education only. What's right for you depends on your health and your medications, so check with your provider before you start or switch. Book a consult
Our top pick
Every form, in plain words
The PA-free cream
Comfrey cream or ointment labeled free of pyrrolizidine alkaloids
The form used in studies, made to remove most of the liver-harming compounds (PAs).
Good for: Bruises & bumps · Sore muscles
Usually skip
- The other creams (Other comfrey creams or salves)May have more PAs, liver-harming compounds that can get through the skin.
- Never swallow (Comfrey tea, capsules, or tincture)It has caused serious liver damage, and the FDA advised removing it from oral supplements.
Spotting a good one on the shelf
Look for
- Look for 'Comfrey cream or ointment labeled free of pyrrolizidine alkaloids' on the label (the PA-free cream)
Watch out for
- Not labeled 'PA-free' (free of liver-harming pyrrolizidine alkaloids)
- Any comfrey product meant to be swallowed
Check with your provider first if…
- Never take it by mouth
- Use only on unbroken skin, and only for short periods. Ask your provider how long.
- Pregnancy or breastfeeding: avoid it completely
- Liver disease, or taking medicines that can affect the liver
Ready to find the root cause?
Dr. Lesher is a Naturopathic Doctor who focuses on autoimmune and chronic conditions in women. Since 2020, she's helped hundreds of patients stop managing symptoms and start healing.